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Prions: a challenge for science, medicine ( Cód. : 14pa>344 )

Prions: a challenge for science, medicine and public health system

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Autor/es:

Rabenau, H.F.; Cinalt, J. y Doerr, H.W.

Año:

2001

Idioma:

Inglés

Categoría:

Libro

Características:

164 páginas

192,94 € (4,00% IVA incluido)

In the past decades, the public has been forced to revise its perception of the apparent triumph of modern hygiene and medical microbiology over infectious diseases. Not only have order infections reemerged but new epidemics, like AIDS, have lead to public uncertainty. With the onset of the bovine spongiform encephalopathy epidemic in Great Britain, novel infectious agents came into the public spotlight, ones that do not cause classical inflammation but a slow and irreversible degeneration of the central nervous system. Sensational from a scientific point of view, these agents, called proteinaceous infectious organisms or prions, were shown to be self-replicating without nucleic acid sequences to encode genomic information. In this volume, leading scientists deal with the medical, scientific and public health questions that prion infections raise. Besides the 'prion or virus' discussion, the structures of prions and their molecular biological analysis as well as the questions of strain variations and species barrier are presented. The etiological, clinical and diagnostic aspects of transmissible spongiform encephalopathies are given special attention. The epidemiology of human and animal prion diseases, disease management and possibilities for inactivation of prions are discussed from a public health perspective. Directed at scientists, physicians and the public health sector, the monograph uses a multidisciplinary approach to present the latest findings on prion infection.

INDICE: Transmissible Spongiform Encephalopathies: The Viral Concept and an Application: Diringer, H. The Prion Theory: Background and Basic Information: Riesner, D. [URE3] and [PSI]: Prions of Saccharomyces cerevisiae: Taylor, K.L.; Wickner,R.B. Structural Biology of Prions: Cappai, R.; Jobling, M.F.; Barrow, C.J.; Collins, S. Strain Variations and Species Barriers: Hill, A.F.; Collinge, J. Resistance of Transmissible Spongiform Encephalopathy Agents to Decontamination: Taylor, D.M. Human Prion Diseases: Cause, Clinical and Diagnostic Aspects: Knight, R.; Collins, S. Epidemiology and Risk Factors of Transmissible Spongiform Encephalopathies in Man: Zerr, I.; Poser, S. Bovine Spongiform Encephalopathy and Its Relationship to the New Variant Form of Creutzfeldt-Jakob Disease. An Account of Bovine Spongiform Encephalopathy, Its Cause, the Clinical Signs and Epidemiology Including the Transmissibility of Prion Diseases with Special Reference to the Relationship between Bovine Spongiform Encephalopathy and the Variant Form of Creutzfeldt-Jakob Disease: Bradley, R. Animal Transmissible Spongiform Encephalopathy: Clinical and Diagnostic Aspects: Kaaden, O.-R. The Challenge for the Public Health System: Minor, P.D. Author Index

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